If a result in your patient portal is marked critical, or you see a number that looks dangerously high or low and you feel unwell, do not wait for a callback. Call the clinician who ordered the test right now. If you also have chest pain, trouble breathing, confusion, fainting, or severe weakness, call 911 or go to the nearest emergency department.
If you feel fine and the result is only flagged high or low, it is usually not an emergency. A message or phone call during business hours is the right speed.
The hard part is telling those two situations apart when the result lands on your phone at 9 p.m. and nobody has explained it. So here is how it works, which numbers matter, and what to do.
Why results show up before anyone has called you
The 21st Century Cures Act information-blocking rules changed the default. The prohibition began applying on April 5, 2021, and from October 6, 2022 it covered the full electronic health information in the designated record set rather than a narrower list of data elements (1). Federal guidance does not tell health systems to push every result to you the moment it posts. It does say that once a patient asks for access, the response has to be timely, and in practice you may see a result at about the same time the ordering clinician does (2).
Holding results back for clinician review is hard to defend as a blanket policy. The same federal FAQs say a routine several-day delay across a broad range of results does not qualify for the Preventing Harm exception (3). An individual clinician can make a specific determination that releasing one result would put someone’s life or physical safety at risk, and a patient can ask for a delay on their own results (3,4). Enforcement is no longer theoretical either. Provider disincentives tied to Medicare programs were finalized in July 2024, and HHS announced in September 2025 that information-blocking enforcement is a priority (5).
Patients, for what it is worth, mostly like this. In a four-center survey of 8,139 people, 95.7 percent wanted results in the portal immediately, even before a clinician reviewed them. But 16.5 percent of people with not-normal results reported being more worried afterward, against 5.0 percent of those with normal results (6). That worry is what this post is for.
What does “critical” actually mean?
A critical value is a lab result that suggests something imminently life-threatening. Federal lab regulations under CLIA require the laboratory to immediately alert the person who requested the test when a result indicates an imminently life-threatening condition, or a panic or alert value (7). The Joint Commission describes a critical value as one requiring immediate communication of results (8).
Notice who gets the call. The lab calls the ordering clinician, not you. One hospital laboratory described its rule as a technologist phoning the ordering practitioner within 30 minutes, with escalation if that person cannot be reached (8). Each lab builds its own list and its own cutoffs, and accreditors including the College of American Pathologists and the Joint Commission expect an alert system to exist (8). That obligation runs separately from whatever your portal shows you.
What the portal shows is a different matter. ONC’s safety guide for test result reporting recommends that critical values be flagged differently from ordinary abnormal values in the record clinicians use (9). Whether your portal does the same depends on the system. Do not count on a special color or the word “critical” appearing.
Flagged does not mean dangerous
Reference ranges are built from the central 95 percent of results in a healthy group. By definition, that labels 5 percent of healthy people as abnormal on any single test (10). Order a panel of 20 tests and about 64 percent of healthy people will have at least one result flagged (10). MedlinePlus puts it plainly: it is common for healthy people to sometimes have results outside the reference range (11).
So the red H or L next to your result is a prompt to look, not a verdict. A potassium of 5.6 mmol/L, for example, sits in the mild band (5.5 to 5.9) of the UK Kidney Association’s hyperkalaemia grading, and the same guideline says most mild or moderate cases found in the community can be managed without admission unless the person is acutely unwell (12). A sodium of 132 falls in the mild hyponatremia band, 130 to 135 (13). Both are real findings that deserve a conversation. Neither is a 911 call in a person who feels well.
One more trap. A hemolyzed blood sample can make potassium read falsely high, and that guideline recommends paired samples when this pseudo-hyperkalaemia is suspected (12). A surprising potassium in someone with no symptoms and normal kidney function is a reasonable one to repeat before anyone panics.
Which numbers can be truly urgent?
Labs call a wide range of analytes. Electrolytes, especially potassium, hemoglobin, high blood glucose and positive blood cultures were all on one laboratory survey’s list of commonly called values (8). I am not going to hand you a universal cutoff for each, because your lab sets its own. But the published guidelines give a sense of where the danger starts.
Potassium first. The UK Kidney Association grades severe hyperkalaemia as 6.5 mmol/L or higher and recommends urgent hospital assessment for anyone with that level found in the community (12). Sodium next. The European hyponatraemia guideline calls a serum sodium below 125 mmol/L profound, and notes that symptoms become more common below that level. Nausea, confusion and headache count as moderately severe symptoms. Vomiting, seizures, deep sleepiness and coma count as severe (13).
Glucose runs both directions. The American Diabetes Association defines level 2 hypoglycemia as below 54 mg/dL, and level 3 as an event with altered mental or physical status that needs another person’s help, whatever the glucose number says (14). On the high side, the ADA says to seek immediate care if you cannot keep fluids down, have ongoing vomiting, or have altered mental status (14). Those symptoms matter more than the number.
Hemoglobin is context-heavy. In the 2023 AABB guideline, the transfusion threshold for stable hospitalized adults is below 7 g/dL (15). That is a transfusion trigger and not a lab’s critical cutoff, but it tells you what kind of low is alarming. A slowly developed anemia and a bleed produce very different pictures at the same number.
Troponin deserves its own warning because patients see it more often now. Each assay has its own 99th percentile cutoff, reported in ng/L, and a value above it means myocardial injury. It is sensitive for a heart attack but not specific for one (16). If you see an elevated troponin in your portal and you have chest pressure, shortness of breath, or pain spreading to the arm or jaw, call 911 immediately (17). My view is that an unneeded trip to the emergency department is a much better outcome than a delayed one.
Some results always get a phone call from me: a critical blood sugar, a critical potassium, a critical kidney function result, or another electrolyte in the critical range. It is easier to reach someone during office hours, but I treat a critical result as urgent no matter what time it comes in. A critical number can occasionally be a mistake, too. A lab error, or a hemolyzed sample, where red cells broke open after the draw, can show an artificially high potassium. That is one reason earlier results help so much. For new patients I try to get their previous lab work, so I have something to compare against when I order new tests. It isn’t always possible.
What to do, in order
Start with how you feel, not with the number. Any chest pain, trouble breathing, fainting, new confusion, seizure, or severe weakness means 911, whatever the result says.
If you feel okay, check the reference range printed on your own report and read the lab’s comment, if there is one. Then call the office that ordered the test. Portal messages are the wrong tool for anything you think might be urgent. Pick up the phone.
After hours, call anyway and ask for the on-call clinician. If no one can be reached and the value is in the range described above (a potassium of 6.5 or higher, or a sodium under 125), go to an emergency department. A drawn glucose is old news by the time you read it, so for glucose, how you feel right now decides. Bring the result, your medication list, and the name of the ordering clinician.
Do not wait for the next business day with a severe value because you assume someone has already been called. The lab alert exists, but a phone number can be wrong and a message can sit in a queue.
When a virtual clinician ordered the test
Telehealth adds a wrinkle. The lab you walked into is probably near your home, while the clinician who ordered the test may be in another city or time zone. The ONC guide says the ordering clinician is responsible for follow-up of outpatient results unless that responsibility is delegated to someone else, and the delegation should be documented and accepted (9). That is the right principle. You want to know that someone actually holds it.
Ask which phone number the lab has on file for the ordering clinician, and whether that number is monitored when the clinician is not in a visit. Make sure the lab has your current cell number. And know where you are during a video visit, because a clinician who needs to send help has to know your physical address.
When a lab I ordered comes back critical, I try to reach the patient directly, especially after hours, because they need to know. They may know before I do, since the lab sometimes releases the result to them first. I also try to loop in their primary care physician if they have one. And a local emergency contact in the chart helps in the situations where the patient can’t be reached.
Ask before the blood draw
The single best question is “Who calls me if a result is critical, and from what number?” Ask it when the test is ordered, not when the portal pings you.
Follow with three more. Will I see results before you have read them? Who covers if you are unavailable? And if I would rather talk first, can the release wait? Federal guidance treats a patient’s own request to delay as likely not an interference, as long as the delay lasts no longer than necessary to meet that request (4). Some people genuinely prefer to hear a frightening result from a person first. That is a legitimate choice.
For patients, and for clinicians
If you are the patient
Know your own phone number on file, keep your ringer on after a blood draw, and decide ahead of time who you will call. Write the question “who calls me if it is critical” in your notes app before the next lab visit. Treat symptoms as the deciding factor.
If you are the clinician
Tell patients when you order that results may post before you have seen them, since the evidence shows abnormal results raise worry more often (6). Keep your critical-value contact information current with every lab you use, and make sure patients know who is covering when you are not. The SAFER guide asks organizations to have policies for timely patient notification of both normal and abnormal results, with the timeliness monitored (9).
When I order labs, I tell patients which tests are on the list. For my patients that usually means a fasting lipid profile, a comprehensive metabolic panel, a TSH, a hemoglobin A1c, and a high-sensitivity C-reactive protein, plus two special lipid tests: lipoprotein(a), which the 2026 ACC/AHA dyslipidemia guideline recommends measuring at least once in every adult (18), and apolipoprotein B.
The Bottom Line
A result marked critical, or a very high or low number paired with symptoms, means call the ordering clinician now, and call 911 for chest pain, trouble breathing, confusion, or fainting. A result that is merely flagged high or low is common even in healthy people and can usually wait for a conversation.
Cures Act rules mean you will often see results first, so ask before the blood draw who calls you if something is critical, from what number, and what happens when they cannot reach you. For telehealth patients, that answer matters even more.
Related Reading
When to Use Telemedicine vs. Urgent Care: How I Spot the Sick One
Emergency Room vs Urgent Care: Which Should You Choose?
Chest Pain: Could It Be a Warning Sign of a Heart Attack?
Why Some Conditions Need an In-Person Visit, Not Virtual Care
More on Healthcare System & Technology
Scott Rennie, D.O.
Board Certified in Obesity Medicine and Family Medicine
This blog is for educational purposes only and does not constitute individual medical advice. Always consult your own physician before making changes to your health, medications, or treatment plan.
Sources
- Department of Health and Human Services. Information Blocking and the ONC Health IT Certification Program: Extension of Compliance Dates and Timeframes in Response to the COVID-19 Public Health Emergency. Federal Register, November 4, 2020. https://www.govinfo.gov/content/pkg/FR-2020-11-04/html/2020-24376.htm
- ASTP/ONC. FAQ: Are actors (for example, health care providers) expected to release test results to patients through a patient portal or API as soon as the ordering clinician can see them? https://healthit.gov/faq/are-actors-example-health-care-providers-expected-release-test-results-patients-through-patient/
- ASTP/ONC. FAQ: Would the Preventing Harm Exception cover a blanket several-day delay in the release of laboratory or other test results? https://healthit.gov/faq/would-preventing-harm-exception-cover-blanket-several-day-delay-release-laboratory-or-other/
- ASTP/ONC. FAQ: Can an actor grant a patient’s request to delay the release of the patient’s test results? https://healthit.gov/faq/can-actor-grant-patients-request-delay-release-patients-test-results-eg-laboratory-or-image/
- Liebler AJ, Sullivan S, Boyer MD, Doe K. Information Blocking Enforcement Enters a New Phase: What Digital Health Stakeholders Should Expect in 2026. Alston & Bird Health Care Advisory. February 23, 2026. https://www.alston.com/en/insights/publications/2026/02/information-blocking-enforcement-2026
- Steitz BD, Turer RW, Lin CT, et al. Perspectives of patients about immediate access to test results through an online patient portal. JAMA Netw Open. 2023;6(3):e233572. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802672
- 42 CFR 493.1291. Test report (CLIA), paragraph (g). https://www.law.cornell.edu/cfr/text/42/493.1291
- Association for Diagnostics & Laboratory Medicine. Critical result notification preferences. Clinical Laboratory News. September-October 2024. https://myadlm.org/cln/Articles/2024/SeptemberOctober/Critical-result-notification-preferences
- ONC. SAFER Guides: Test Results Reporting and Follow-Up. August 2024 self-assessment. https://www.healthit.gov/sites/default/files/topiclanding/2025-01/8.%20Test%20Results%20Reporting%20Final.pdf
- Doles N, Ye Mon M, Shaikh A, et al. Interpreting normal values and reference ranges for laboratory tests. J Am Board Fam Med. 2025;38(1):174-179. https://pmc.ncbi.nlm.nih.gov/articles/PMC12096374/
- MedlinePlus. How to Understand Your Lab Results. Updated September 4, 2025. https://medlineplus.gov/lab-tests/how-to-understand-your-lab-results/
- UK Kidney Association. Clinical Practice Guideline: Management of Hyperkalaemia in Adults. Updated July 2026. https://www.ukkidney.org/sites/default/files/documents/FINAL%20VERSION%20-%20UKKA%20CLINICAL%20PRACTICE%20GUIDELINE%20-%20MANAGEMENT%20OF%20HYPERKALAEMIA%20IN%20ADULTS%20-%20UPDATED%20JULY%202026_0.pdf
- Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol. 2014;170(3):G1-G47. https://doi.org/10.1530/EJE-13-1020
- American Diabetes Association Professional Practice Committee. 6. Glycemic goals, hypoglycemia, and hyperglycemic crises: Standards of Care in Diabetes-2026. Diabetes Care. 2026;49(Suppl 1):S132-S149. https://doi.org/10.2337/dc26-S006
- Carson JL, Stanworth SJ, Guyatt G, et al. Red blood cell transfusion: 2023 AABB international guidelines. JAMA. 2023;330(19):1892-1902. https://doi.org/10.1001/jama.2023.12914
- Sandoval Y, Apple FS, Mahler SA. High-sensitivity cardiac troponin and the 2021 guidelines for acute chest pain. American College of Cardiology. July 14, 2022. https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2022/07/14/18/12/high-sensitivity-ctn-and-2021-chest-pain
- Centers for Disease Control and Prevention. About Heart Attack Symptoms, Risk, and Recovery. October 24, 2024. https://www.cdc.gov/heart-disease/about/heart-attack.html
- American College of Cardiology. Lower Sooner: How the 2026 Dyslipidemia Guideline Changes Practice. July 1, 2026. https://www.acc.org/latest-in-cardiology/articles/2026/07/01/01/prioritizing-health

