Travel has fully returned, and patients are planning international trips again, with a wide range of destinations and styles. On these video visits, the questions almost always start with vaccines or antibiotics. The real foundation of travel medicine is something else entirely: understanding the specifics of the trip. When I talk with someone preparing to travel, I start with where they are going, how long they will be away, what kind of environment they will be in, and whether they have a chronic condition that might change their risk. Those details matter. A medication or vaccine that is essential for one itinerary may be unnecessary for another.

The first step is confirming routine immunizations. MMR, Tdap, influenza, COVID, and varicella should be current for every traveler, regardless of destination. People sometimes think travel preparation means exotic vaccines. But many illnesses that interrupt trips are the same preventable infections we vaccinate against at home. Once routine protection is confirmed, I look at travel-specific vaccines based on destination and activities. Hepatitis A is worth adding for most international travel where sanitation varies. Hepatitis B belongs on the list for long-term travel, healthcare exposure risk, or an uncertain vaccination history. Typhoid covers travel to many parts of Asia, Africa, and Central America. Yellow fever is required for entry into several countries in sub-Saharan Africa and South America, and Japanese encephalitis matters for long stays in rural areas of Asia or frequent outdoor exposure. Ghana is the example I reach for. Yellow fever vaccination is required for entry, and travelers turn up regularly who have never had it and did not know it was mandatory. That gets sorted first, then malaria prevention if the itinerary runs rural. My view: skipping a vaccine that’s actually required for entry is the most avoidable mistake I see. It’s an easy one to catch, too, if we go through the itinerary first.

Rabies vaccination before travel is another example of something that depends heavily on the details. Someone visiting large cities in Europe for a week has almost no need for it. Someone staying in remote areas, volunteering with animals, or hiking in places where medical care is difficult to access may benefit from receiving it ahead of time. Exposure risk drives that decision, not the destination’s reputation.

Antibiotics come up frequently, and this is where expectations and guidelines often differ. Many travelers assume an antibiotic is something they should take with them in case they get sick. In reality, travelers diarrhea is the most common illness during international travel. Most mild cases respond to hydration and over the counter medications rather than antibiotics. When antibiotics are appropriate, the choice depends on symptom severity and regional resistance patterns. Rural Cambodia is the one that comes up. Travelers remember taking ciprofloxacin on a previous trip and want it again. Updated resistance data has made ciprofloxacin a poor choice there, so the plan changes, and food and water safety carries more of the load. My own bias here. I’d rather a patient carry the right antibiotic and never use it than assume hydration will be enough on a five-day trek.

For a basic travel kit, I usually start with acetaminophen and ibuprofen, which cover pain, fever, and the aches that come with viral illnesses; for gastrointestinal symptoms, loperamide and bismuth subsalicylate handle most mild travelers diarrhea, and oral rehydration salts matter just as much, since dehydration from diarrhea or heat is often the bigger problem than the diarrhea itself. If nausea or motion sickness is a concern, I’ll prescribe ondansetron ahead of time. For moderate or severe diarrhea, azithromycin or a clinician-selected alternative is the antibiotic I reach for, not something to use for every loose stool. Acetazolamide comes up for rapid ascent or high-altitude destinations. For malaria prevention, the choice sits between atovaquone-proguanil, doxycycline, and mefloquine. It depends on the region, the length of the trip, and the traveler’s medical history. Antihistamines and intranasal steroids round out the kit for anyone with seasonal or environmental triggers.

Safety planning is a major part of effective travel preparation, but it often gets the least attention; we discuss how to carry a medication list, a brief summary of medical conditions, and insurance information, along with knowing how to access care in the destination country. Food and water hygiene still matters in many regions. So does mosquito protection for illnesses like dengue and chikungunya that do not have widely recommended vaccines for travelers. For destinations with malaria risk, prophylactic medications and mosquito avoidance measures remain a core part of the plan; and for high altitude trips, preventive medications can help if ascent is rapid or unavoidable. If I had to rank these, food and water discipline prevents more sick days than any pill I prescribe. A basic first aid kit rounds this out: adhesive bandages for cuts, scrapes, and blisters; sterile gauze and medical tape for larger wounds; antibiotic ointment to prevent minor wound infections; hydrocortisone cream for itching and insect bites; alcohol or antiseptic wipes to clean a wound before dressing it; tweezers for splinters or ticks; an elastic compression wrap for sprains or mild injuries; a digital thermometer, essential for evaluating fever or illness on the road; and gloves for basic hygiene when handling a wound.

Many travelers also assume they need more than they actually do. Someone visiting Western Europe with up to date routine vaccines usually does not need any additional travel specific vaccines. Travelers often believe they need antibiotics for every trip or that malaria medication protects them from dengue or chikungunya. Which it does not. Correcting these misconceptions is, in my view, as valuable as any vaccine I give: it keeps people from paying for protection they don’t need.

Combine all of this with a clear discussion of itinerary, health history, and realistic risk. Most travelers leave the visit feeling better prepared, not overwhelmed by unnecessary steps. Travel medicine should be individualized. What someone needs for a two week trip to Western Europe is very different from what is needed for remote backpacking in Southeast Asia or trekking at high altitude in Peru. Once the plan matches the destination, everything else becomes much clearer.

Scott Rennie, D.O.

Sources

CDC Yellow Book (cdc.gov)

CDC Travel Vaccine Guide (cdc.gov)

CDC Travelers Diarrhea (cdc.gov)

WHO Travel and Health (who.int)

WHO International Travel Requirements (who.int)

UPMC Travel Health (upmc.com)

TravelHealthPro (travelhealthpro.org.uk)

National Library of Medicine Travelers Diarrhea Review (ncbi.nlm.nih.gov)

Pyllola Travel Vaccines Guide (pyllola.com)

Immunize.org Travel Vaccines (immunize.org)

Board Certified in Obesity Medicine and Family Medicine

This blog is for educational purposes only and does not constitute individual medical advice. Always consult your own physician before making changes to your health, medications, or treatment plan.